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PIK3CA (p.E542K)

Variant Data

Location

  • HGVS: ENST00000263967:c.1624G>A
  • Reference Version: GRCh37
  • Chromosome: 3
  • Start: 178936082
  • Stop: 178936082
  • Strand: 1
  • Transcript: ENST00000263967 (ensembl - 74_37)
  • Gene: PIK3CA ( View drug interactions on DGIdb )

Information

Disease Data

Disease Source Batch Tags External Links
colorectal cancer Samuels et al., 2004, Science My Cancer Genome (View variants) pathogenic My Cancer Genome
non-small cell lung carcinoma Samuels et al., 2004, Science My Cancer Genome (View variants) pathogenic My Cancer Genome
colorectal cancer Bachman et al., 2004, Cancer Biol. Ther. My Cancer Genome (View variants) pathogenic My Cancer Genome
non-small cell lung carcinoma Bachman et al., 2004, Cancer Biol. Ther. My Cancer Genome (View variants) pathogenic My Cancer Genome
breast cancer Bachman et al., 2004, Cancer Biol. Ther. My Cancer Genome (View variants) pathogenic My Cancer Genome
colorectal cancer Kang et al., 2005, Proc. Natl. Acad. Sci. U.S.A. My Cancer Genome (View variants) pathogenic My Cancer Genome
non-small cell lung carcinoma Kang et al., 2005, Proc. Natl. Acad. Sci. U.S.A. My Cancer Genome (View variants) pathogenic My Cancer Genome
ovarian cancer Kang et al., 2005, Proc. Natl. Acad. Sci. U.S.A. My Cancer Genome (View variants) pathogenic My Cancer Genome
breast cancer Kang et al., 2005, Proc. Natl. Acad. Sci. U.S.A. My Cancer Genome (View variants) pathogenic My Cancer Genome, Civic logo CIViC
breast cancer Saal et al., 2005, Cancer Res. My Cancer Genome (View variants) pathogenic My Cancer Genome
non-small cell lung carcinoma Engelman et al., 2006, J. Clin. Invest. My Cancer Genome (View variants) pathogenic My Cancer Genome
non-small cell lung carcinoma Kawano et al., 2006, Lung Cancer My Cancer Genome (View variants) pathogenic My Cancer Genome
breast cancer Stemke-Hale et al., 2008, Cancer Res. My Cancer Genome (View variants) pathogenic My Cancer Genome
colorectal cancer She et al., 2008, PLoS ONE My Cancer Genome (View variants) pathogenic My Cancer Genome
non-small cell lung carcinoma She et al., 2008, PLoS ONE My Cancer Genome (View variants) pathogenic My Cancer Genome
breast cancer She et al., 2008, PLoS ONE My Cancer Genome (View variants) pathogenic My Cancer Genome
non-small cell lung carcinoma Engelman et al., 2008, Nat. Med. My Cancer Genome (View variants) pathogenic My Cancer Genome
colorectal cancer Prenen et al., 2009, Clin. Cancer Res. My Cancer Genome (View variants) pathogenic My Cancer Genome
non-small cell lung carcinoma Zou et al., 2009, Int. J. Mol. Med. My Cancer Genome (View variants) pathogenic My Cancer Genome
colorectal cancer He et al., 2009, Clin. Cancer Res. My Cancer Genome (View variants) pathogenic My Cancer Genome
colorectal cancer O'Brien et al., 2010, Clin. Cancer Res. My Cancer Genome (View variants) pathogenic My Cancer Genome
non-small cell lung carcinoma O'Brien et al., 2010, Clin. Cancer Res. My Cancer Genome (View variants) pathogenic My Cancer Genome
breast cancer O'Brien et al., 2010, Clin. Cancer Res. My Cancer Genome (View variants) pathogenic My Cancer Genome
colorectal cancer De Roock et al., 2010, Lancet Oncol. My Cancer Genome (View variants) pathogenic My Cancer Genome
non-small cell lung carcinoma Sequist et al., 2011, Sci Transl Med My Cancer Genome (View variants) pathogenic My Cancer Genome
colorectal cancer Clarke et al., 2012, J. Clin. Oncol. My Cancer Genome (View variants) pathogenic My Cancer Genome
breast cancer Clarke et al., 2012, J. Clin. Oncol. My Cancer Genome (View variants) pathogenic My Cancer Genome
colorectal cancer Bendell et al., 2012, J. Clin. Oncol. My Cancer Genome (View variants) pathogenic My Cancer Genome
non-small cell lung carcinoma Bendell et al., 2012, J. Clin. Oncol. My Cancer Genome (View variants) pathogenic My Cancer Genome
breast cancer Bendell et al., 2012, J. Clin. Oncol. My Cancer Genome (View variants) pathogenic My Cancer Genome
ovarian cancer Janku et al., 2012, J. Clin. Oncol. My Cancer Genome (View variants) pathogenic My Cancer Genome
breast cancer Janku et al., 2013, Cancer Res. Literature (View variants) likely pathogenic
breast cancer MacConaill et al., 2014, J Mol Diagn Oncomap Variants (View variants) likely pathogenic
breast cancer Chang et al., 2016, Nat. Biotechnol. Pan-cancer recurrent hotspots (View variants) likely pathogenic
head and neck squamous cell carcinoma Chang et al., 2016, Nat. Biotechnol. Pan-cancer recurrent hotspots (View variants) likely pathogenic
uterine corpus endometrial carcinoma Chang et al., 2016, Nat. Biotechnol. Pan-cancer recurrent hotspots (View variants) likely pathogenic
colorectal cancer Chang et al., 2016, Nat. Biotechnol. Pan-cancer recurrent hotspots (View variants) likely pathogenic
cervix carcinoma Chang et al., 2016, Nat. Biotechnol. Pan-cancer recurrent hotspots (View variants) likely pathogenic
urinary bladder urothelial carcinoma Chang et al., 2016, Nat. Biotechnol. Pan-cancer recurrent hotspots (View variants) likely pathogenic
gastric adenocarcinoma Chang et al., 2016, Nat. Biotechnol. Pan-cancer recurrent hotspots (View variants) likely pathogenic
lung adenocarcinoma Chang et al., 2016, Nat. Biotechnol. Pan-cancer recurrent hotspots (View variants) likely pathogenic
esophageal carcinoma Chang et al., 2016, Nat. Biotechnol. Pan-cancer recurrent hotspots (View variants) likely pathogenic
lung squamous cell carcinoma Chang et al., 2016, Nat. Biotechnol. Pan-cancer recurrent hotspots (View variants) likely pathogenic
prostate adenocarcinoma Chang et al., 2016, Nat. Biotechnol. Pan-cancer recurrent hotspots (View variants) likely pathogenic
brain glioma Chang et al., 2016, Nat. Biotechnol. Pan-cancer recurrent hotspots (View variants) likely pathogenic
glioblastoma multiforme Chang et al., 2016, Nat. Biotechnol. Pan-cancer recurrent hotspots (View variants) likely pathogenic
lung small cell carcinoma Chang et al., 2016, Nat. Biotechnol. Pan-cancer recurrent hotspots (View variants) likely pathogenic
hepatocellular carcinoma Chang et al., 2016, Nat. Biotechnol. Pan-cancer recurrent hotspots (View variants) likely pathogenic
papillary renal cell carcinoma Chang et al., 2016, Nat. Biotechnol. Pan-cancer recurrent hotspots (View variants) likely pathogenic
breast cancer Tanaka et al., 2011, Clin. Cancer Res. CIViC Knowledgebase (View variants) Civic logo CIViC
colorectal cancer Sartore-Bianchi et al., 2014, Expert Rev Anticancer Ther CIViC Knowledgebase (View variants) Civic logo CIViC
colorectal cancer Sartore-Bianchi et al., 2009, Cancer Res. CIViC Knowledgebase (View variants) Civic logo CIViC
colorectal cancer Liao et al., 2012, Clin. Cancer Res. CIViC Knowledgebase (View variants) Civic logo CIViC
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